Multivalent iminosugars to modulate affinity and selectivity for glycosidases.
نویسندگان
چکیده
A series of mono-, di- and tri-valent iminosugars based on oligoethylene scaffolds and N-substituted deoxynojirymicin epitopes have been synthesized by "click chemistry" to study the effect of multivalency on glycosidase inhibition. Biological evaluation evidenced differences in the inhibition trends as a function of the enzyme nature. The results demonstrate that multivalency can be used in some case to modulate both the affinity and the selectivity of glycosidase inhibition.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 7 2 شماره
صفحات -
تاریخ انتشار 2009